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Here is a review paper on the “Management of Osteoarthritis During the Covid_19 Pandemic”. This paper would provide orthopedic surgeons in particular, and physicians, pharmacologists, and clinicians in general, a comprehensive description about the safety of the current pharmacological approaches and a decision‐making tool to treat their OA patients as the coronavirus pandemic continues.
 
 
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The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and Springer Healthcare have recently published the Atlas of Osteoarthritis
Find out more about:
– Historical perspectives on the desease
– Pathophysiology
‍- Clinical features and diagnosis and
– Treatment of osteoarthritis
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“In the past three decades, we have experienced an explosion of knowledge in all areas of medicine. The increasing use of “wearables” in everyday life in recent years, decreasing prices of biotechnical methods, and improved understanding of biomarkers and genetic sequencing methods, are creating unprecedented new opportunities, especially within rheumatology.

With the accelerating flow of scientific data, our knowledge grows rapidly, but also shows an immense growth in complexity”.

For more information click here

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ICH E6 (R2) requires sponsors to maintain responsibility for oversight of vendors, including those handling your clinical trial data. This often is challenging, particularly for companies with limited or no biometrics departments internally. Correct and effective data oversight increases your confidence in your clinical trial results and supports progress of development programs. During this webinar, we will review the components of biometrics oversight, assess various approaches, suggest an effective data oversight strategy and present case studies. The key learning outcomes will be:

• Understanding of the importance of oversight for clinical trial data

• How to choose the right approach to data oversight

• What are the fundamental components of an oversight program

For more information click here

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How healthcare stakeholders can win within evolving healthcare ecosystems.

“The healthcare ecosystems of the future will likely be defined by the needs of different patient populations and their associated effective care journeys (including beyond care itself). The consumer-oriented nature of these ecosystems also will increase the number of healthcare touchpoints, with the goal of modifying patient behavior and improving outcomes.

Healthcare ecosystems will emerge to address the needs of healthy patients, who have less consistent medical challenges, but often set personal wellness goals. These patients will likely experience a more digital ecosystem, where patient data and insights are consumed in a highly personalized and meaningful way, such as with wearable devices. Only a small percentage of the touchpoints would be in modalities of traditional care.”

For more information click here

 

 

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Cartilage matrix is a composite of discrete, but interacting suprastructures, i.e. cartilage fibers with microfibrillar or network-like aggregates and penetrating extrafibrillar proteoglycan matrix. The biomechanical function of the proteoglycan matrix and the collagen fibers are to absorb compressive and tensional loads, respectively. Here, we are focusing on the suprastructural organization of collagen fibrils and the degradation process of their hierarchical organized fiber architecture studied at high resolution at the authentic location within cartilage. We present electron micrographs of the collagenous cores of such fibers obtained by an improved protocol for scanning electron microscopy (SEM). Articular cartilages are permeated by small prototypic fibrils with a homogeneous diameter of 18 ± 5 nm that can align in their D-periodic pattern and merge into larger fibers by lateral association. Interestingly, these fibers have tissue-specific organizations in cartilage. They are twisted ropes in superficial regions of knee joints or assemble into parallel aligned cable-like structures in deeper regions of knee joint- or throughout hip joints articular cartilage. These novel observations contribute to an improved understanding of collagen fiber biogenesis, function, and homeostasis in hyaline cartilage.

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Osteoarthritis (OA) is a chronic degenerative disease of the articular joint that involves both bone and cartilage degenerative changes. An engineered osteochondral tissue within physiological conditions will be of significant utility in understanding the pathogenesis of OA and testing the efficacy of potential disease-modifying OA drugs (DMOADs). In this study, a multichamber bioreactor was fabricated and fitted into a microfluidic base. When the osteochondral construct is inserted, two chambers are formed on either side of the construct (top, chondral; bottom, osseous) that is supplied by different medium streams. These medium conduits are critical to create tissue-specific microenvironments in which chondral and osseous tissues will develop and mature. Human bone marrow stem cell (hBMSCs)-derived constructs were fabricated in situ and cultured within the bioreactor and induced to undergo spatially defined chondrogenic and osteogenic differentiation for 4 weeks in tissue-specific media. We observed tissue specific gene expression and matrix production as well as a basophilic interface suggesting a developing tidemark. Introduction of interleukin-1β (IL-1β) to either the chondral or osseous medium stream induced stronger degradative responses locally as well as in the opposing tissue type. For example, IL-1β treatment of the osseous compartment resulted in a strong catabolic response in the chondral layer as indicated by increased matrix metalloproteinase (MMP) expression and activity, and tissue-specific gene expression. This induction was greater than that seen with IL-1β application to the chondral component directly, indicative of active biochemical communication between the two tissue layers and supporting the osteochondral nature of OA. The microtissue culture system developed here offers novel capabilities for investigating the physiology of osteochondral tissue and pathogenic mechanisms of OA and serving as a high-throughput platform to test potential DMOADS.

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Software is present at all levels, at the interface with low level hardware though to the interface with end users, and everything in between.
But the nature of software raises many issues concerning its management, protection and exploitation. This is due to the range of different application areas; its ability to operate globally; its fast rate of development, adaptation and change; and its composite nature. Because we also live in an interconnected world, software needs to manage its interfaces, and to take into consideration formal and de-facto standards, to ensure seamless interoperability.

This webinar will look at some specific issues concerning the protection and exploitation of software, such as the most appropriate IP Rights to use (e.g. patents, database rights, etc), and different exploitation models for design tools, product and services (e.g. Open Source licensing, start-ups, etc).
This webinar is relevant for all those involved with developing and exploiting software tools, products and services; or acquiring or licensing it in; whether they are SMEs, large companies or researchers.

For more information click here

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What was once a science fiction fantasy, virtual reality (VR) technology has evolved and come a long way. Together with augmented reality (AR) technology, these simulations of an alternative environment have been incorporated into rehabilitation treatments. The introduction of head-mounted displays has made VR/AR devices more intuitive and compact, and no longer limited to upper-limb rehabilitation. However, there is still limited evidence supporting the use of VR and AR technology during locomotion, especially regarding the safety and efficacy relating to walking biomechanics. Therefore, the objective of this study is to explore the limitations of such technology through gait analysis. In this study, thirteen participants walked on a treadmill in normal, virtual and augmented versions of the laboratory environment.👇👇👇

https://tbirehabilitation.wordpress.com/2020/04/02/article-walking-with-head-mounted-virtual-and-augmented-reality-devices-effects-on-position-control-and-gait-biomechanics-full-text-pdf/

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The EULAR 2019 Congress takes place from 12-15 June 2019, in Madrid Spain. The European League Against Rheumatism (EULAR) is the organisation which represents the patient, health professional and scientific societies of rheumatology of all the European nations. The aim of the congress is to provide a forum of the highest standard for scientific, educational and social exchange between professionals involved in rheumatology, liaising with patient organisations, in order to achieve progress in the clinical care of people with rheumatic diseases. Have a look at the topics the congress is covering: 👇👇👇https://www.congress.eular.org/abstract_topics.cfm

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